Prednisolone Side Effects in the UK – Quick Facts and Practical Advice

If you’ve been prescribed prednisolone, you probably wonder what it might do to your body. It’s a powerful corticosteroid that can calm inflammation fast, but it also brings a mix of side effects. Below we break down the most common reactions, the rarer ones that need urgent attention, and how you can reduce the risk while staying on the medication.

What to Expect: Common Side Effects

Most people feel at least a few of these when they start prednisolone:

• Weight gain – especially around the belly and face.
• Increased appetite – you might find yourself snacking more.
• Sleep trouble – insomnia or restless nights are common.
• Mood swings – irritability, anxiety, or feeling ‘up‑and‑down’.
• Skin changes – thinning skin, easy bruising, or acne‑like eruptions.

These effects usually appear early and can ease off if the dose is lowered or the treatment is short‑term. Stay hydrated, watch your diet, and talk to your doctor about a tapering plan if you notice these symptoms getting worse.

Rare but Serious Reactions – When to Call a Doctor

Although they’re less frequent, some side effects need immediate medical attention:

• High blood pressure – sudden spikes can lead to headaches or dizziness.
• Blood sugar spikes – prednisolone can trigger diabetes‑like symptoms, especially in people with existing risk.
• Severe infections – the drug weakens your immune system, so look out for fever, persistent cough, or unusual skin infections.
• Stomach ulcers – intense stomach pain, black stools, or vomiting blood require urgent care.
• Bone loss – long‑term use can cause osteoporosis, leading to fractures from minor falls.

If any of these pop up, call your GP straight away. Adjusting the dose or switching medications can often prevent escalation.

In the UK, NHS guidelines suggest the lowest effective dose for the shortest possible time. This approach limits the chance of both short‑term and long‑term side effects. Ask your pharmacist whether you need a vitamin D supplement or calcium tablets; they’re often recommended when prednisolone treatment goes beyond a few weeks.

Another tip: keep a side‑effect diary. Jot down when you notice changes, how severe they feel, and any triggers (like meals or stress). Sharing this record with your doctor helps them fine‑tune the dosage and offer targeted advice.

Remember, you’re not alone. Many UK patients manage prednisolone safely by staying informed, watching for warning signs, and maintaining open communication with their healthcare team. With the right precautions, you can benefit from the drug’s anti‑inflammatory power while keeping unwanted side effects in check.